Gomelsky booked the band into his Crawdaddy Club in London, and they were subsequently signed by Mickie Most, an independent producer who secured a contract with EMI's Columbia imprint. A studio session in February 1964 yielded their Columbia debut single, "Baby Let Me Take You Home" (adapted from "Baby Let Me Follow You Down"), which rose to number 21 on the British charts. For years, it was rumored incorrectly that the Animals got their next single, "House of the Rising Sun," from Bob Dylan's first album, but it has been revealed that, like "Baby Let Me Take You Home," the song came to them courtesy of Josh White. In any event, the song -- given a new guitar riff by Valentine and a soulful organ accompaniment devised by Price -- shot to the top of the U.K. and U.S. charts early that summer. This success led to a follow-up session that summer, yielding their first long-playing record, The Animals. Their third single, "I'm Crying," rose to number eight on the British charts. The group compiled an enviable record of Top Ten successes, including "Don't Let Me Be Misunderstood" and "We've Gotta Get Out of This Place," along with a second album, Animal Tracks.

In May of 1965, immediately after recording "We've Gotta Get Out of This Place," Alan Price left the band, citing fear of flying as the reason; subsequent biographies of the band have indicated that the reasons were less psychological. When "House of the Rising Sun" was recorded, using what was essentially a group arrangement, the management persuaded the band to put one person's name down as arranger. Price came up the lucky one, supposedly with the intention that the money from the arranger credit would be divided later on. The money was never divided, however, and as soon as it began rolling in, Price suddenly developed his fear of flying and exited the band. Others cite the increasing contentiousness between Burdon and Price over leadership of the group as the latter's reason for leaving. In any case, a replacement was recruited in the person of Dave Rowberry.

In the meantime, the group was growing increasingly unhappy with the material they were being given to record by manager Mickie Most. Not only were the majority of these songs much too commercial for their taste, but they represented a false image of the band, even if many were successful. "It's My Life," a number seven British hit and a similar smash in America, caused the Animals to terminate their association with Most and with EMI Records. They moved over to Decca/London Records and came up with a more forceful, powerful sound on their first album for the new label, Animalisms. The lineup shifts continued, however: Steel exited in 1966, after recording Animalisms, and was replaced by Barry Jenkins, formerly of the Nashville Teens. Chandler left in mid-1966 after recording "Don't Bring Me Down" and Valentine remained until the end of 1966, but essentially "Don't Bring Me Down" marked the end of the original Animals.

Burdon re-formed the group under the aegis of Eric Burdon and the New Animals, with Jenkins on drums, John Weider on guitar and violin, Danny McCulloch on bass, and Vic Briggs on guitar. He remained officially a solo act for a time, releasing a collection of material called Eric Is Here in 1967. As soon as the contract with English Decca was up, Burdon signed with MGM directly for worldwide distribution, and the new lineup made their debut in mid-1967. Eric Burdon and the New Animals embraced psychedelica to the hilt amid the full bloom of the Summer of Love. By the end of 1968, Briggs and McCulloch were gone, to be replaced by Burdon's old friend, keyboard player/vocalist Zoot Money, and his longtime stablemate, guitarist Andy Summers, while Weider switched to bass. Finally, in 1969, Burdon pulled the plug on what was left of the Animals. He hooked up with a Los Angeles-based group called War, and started a subsequent solo career.

The original Animals reunited in 1976 for a superb album called Before We Were So Rudely Interrupted, which picked up right where Animalisms had left off a decade earlier and which was well-received critically but failed to capture the public's attention. In 1983, a somewhat longer-lasting reunion came about between the original members, augmented with the presence of Zoot Money on keyboards. The resulting album, Ark, consisting of entirely new material, was well received by critics and charted surprisingly high, and a world tour followed. By the end of the year and the heavy touring schedule, however, it was clear that this reunion was not going to be a lasting event. The quintet split up again, having finally let the other shoe drop on their careers and history, and walked away with some financial rewards, along with memories of two generations of rock fans cheering their every note.